3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one

Base Information

• Chemical Name: 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one
• CAS No.: 128745-73-3
• Molecular Formula: C₂₃H₂₂N₂O₆
• Molecular Weight: 422.437
• Mol file: 128745-73-3.mol

Synonyms:3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one

Chemical Property of 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one

There total 3 articles about 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 4-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4-oxobutyrate (128745-71-1) → 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one (128745-73-3)

Guidance literature:

With hydrazine hydrate; In methanol; for 12h; Ambient temperature;

Reference yield:

4-(3,5-di-O-benzoyl-1,4-anhydro-2-deoxy-D-erythro-pent-1-enofuranosyl)-4-oxo-2-butenoic acid (109930-06-5) → 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one (128745-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / H₂ / 10percent Pd-C / tetrahydrofuran; methanol / 12 h / 760 Torr

2: 91 percent / HCl / 12 h / Ambient temperature

3: 87 percent / hydrazine monohydrate / methanol / 12 h / Ambient temperature

With hydrogenchloride; hydrogen; hydrazine hydrate; palladium on activated charcoal; In tetrahydrofuran; methanol;

Reference yield:

4-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4-oxobutyric acid (128745-69-7) → 3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4,5-dihydropyridazin-6(1H)-one (128745-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / HCl / 12 h / Ambient temperature

2: 87 percent / hydrazine monohydrate / methanol / 12 h / Ambient temperature

With hydrogenchloride; hydrazine hydrate; In methanol;

upstream raw materials:

methyl 4-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4-oxobutyrate

4-(3,5-di-O-benzoyl-1,4-anhydro-2-deoxy-D-erythro-pent-1-enofuranosyl)-4-oxo-2-butenoic acid

4-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)-4-oxobutyric acid

Downstream raw materials:

3-(3,5-di-O-benzoyl-2-deoxy-α-D-erythro-pentofuranosyl)pyridazin-6(1H)-one