1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Base Information

Chemical Name:1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine
CAS No.:1197358-17-0
Molecular Formula:C₂₄H₂₀F₂N₄O₂
Molecular Weight:434.445
Hs Code.:

Synonyms:1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

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Chemical Property of 1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Chemical Property:

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Technology Process of 1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

There total 4 articles about 1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34803-66-2
1-(2-pyridyl)piperazine

: 1197357-98-4
4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)benzoic acid

: 1197358-17-0
1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 15126-06-4
methyl 3-iodo-4-hydroxybenzoate

: 1197358-17-0
1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

3.2: pH 1

4.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1131614-23-7
4-difluoromethoxy-3-iodo-benzoic acid methyl ester

: 1197358-17-0
1-{[4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

2.2: pH 1

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; toluene;