2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

Base Information

Chemical Name:2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester
CAS No.:1542703-63-8
Molecular Formula:C₁₉H₂₆NO₄P
Molecular Weight:363.394
Hs Code.:

Synonyms:2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

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Chemical Property of 2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

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Technology Process of 2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

There total 3 articles about 2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1336388-67-0
2-bromo-N-[(S)-1-(p-methoxyphenyl)ethyl]aniline

: 122-52-1
triethyl phosphite

: 1542703-63-8
2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

Guidance literature:: With palladium dichloride; at 180 - 190 ℃; for 2h; Inert atmosphere; Schlenk technique;
DOI:10.1021/om401184n

Reference yield:

: 583-53-9
2,3-dibromobenzene

: 1542703-63-8
2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 26 h / 80 - 100 °C / Inert atmosphere; Schlenk technique

2: palladium dichloride / 2 h / 180 - 190 °C / Inert atmosphere; Schlenk technique

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; In toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/om401184n

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
(S)-1-(4-methoxyphenyl)ethylamine

: 1542703-63-8
2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 26 h / 80 - 100 °C / Inert atmosphere; Schlenk technique

2: palladium dichloride / 2 h / 180 - 190 °C / Inert atmosphere; Schlenk technique

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; In toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/om401184n