diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

Base Information

Chemical Name:diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate
CAS No.:161326-14-3
Molecular Formula:C₁₆H₂₂NO₄P
Molecular Weight:323.329
Hs Code.:

Synonyms:diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

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Chemical Property of diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

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Technology Process of diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

There total 4 articles about diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 263898-73-3
5-acetoxy-5-(t-butoxycarbonyl)-1,5-dihydro-3-methyl-4-(p-tolyl)-2H-pyrrol-2-one

: 122-52-1
triethyl phosphite

: 161326-14-3
diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1246/bcsj.73.497

Reference yield:

: (5-Bromo-4-methyl-3-p-tolyl-1H-pyrrol-2-yl)-phosphonic acid diethyl ester

: 161326-14-3
diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

Guidance literature:: With water; trifluoroacetic acid; at 45 ℃; for 5h; Yield given;
DOI:10.1246/bcsj.67.3320

Reference yield:

: 4-methyl-3-p-tolyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 161326-14-3
diethyl 1,5-dihydro-4-methyl-5-oxo-3-(p-tolyl)-2H-pyrrol-2-ylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / N-iodosuccinimide / acetone / 20 °C

2: 93 percent / toluene / 20 °C

3: 68 percent / diethyl ether-boron trifluoride (1/1) / CH₂Cl₂ / 48 h / 20 °C

With N-iodo-succinimide; boron trifluoride diethyl etherate; In dichloromethane; acetone; toluene; 1: Iodination / 2: Acetoxylation / 3: Substitution;
DOI:10.1246/bcsj.73.497