1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

Base Information

Chemical Name:1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one
CAS No.:1447911-47-8
Molecular Formula:C₂₅H₂₄FN₃O₂
Molecular Weight:417.483
Hs Code.:

Synonyms:1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

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Chemical Property of 1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

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Technology Process of 1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

There total 9 articles about 1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1447911-47-8
1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 1 h / 20 °C

2: copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / dimethyl sulfoxide / 1 h / 120 °C / Sealed tube; Microwave irradiation

3: iron; calcium chloride / ethanol; water / 3 h / 70 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5: acetic acid / 1 h / 90 °C

With copper(l) iodide; iron; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; calcium chloride; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.04.011

Reference yield:

: C₂₅H₂₆FN₃O₃

: 1447911-47-8
1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: With acetic acid; at 90 ℃; for 1h;
DOI:10.1016/j.bmc.2016.04.011

Reference yield:

: 302800-13-1
5-bromo-N-methyl-2-nitroaniline

: 1447911-47-8
1-(2-cyclopentyl-1-methyl-1H-benzimidazol-6-yl)-4-((4-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / dimethyl sulfoxide / 1 h / 120 °C / Sealed tube; Microwave irradiation

2: iron; calcium chloride / ethanol; water / 3 h / 70 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

4: acetic acid / 1 h / 90 °C

With copper(l) iodide; iron; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; calcium chloride; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.04.011