dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

Base Information

Chemical Name:dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate
CAS No.:1353989-08-8
Molecular Formula:C₁₃H₁₄Cl₂N₂O₅
Molecular Weight:349.171
Hs Code.:

Synonyms:dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

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Technology Process of dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

There total 1 articles about dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 38256-25-6
dimethyl (E)-2-oxoglutaconate

: 20248-64-0
4,6-dichloro-1,3-benzenediamine

: 1353989-08-8
dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

Guidance literature:: With copper diacetate; toluene-4-sulfonic acid; In dichloromethane; for 24h; Reflux;
DOI:10.1021/jm201251c

Reference yield:

: 1353989-08-8
dimethyl 5-amino-6,8-dichloro-4-hydroxy-1,2,3,4-tetrahydroquinoline-2,4-dicarboxylate

: 1353989-21-5
N-benzyl-6,8-dichloro-1-methyl-2-oxo-1,2-dihydropyrrolo[4,3,2-d,e]quinoline-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / 90 °C

2: triethylamine / dichloromethane / 24 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 1 h / 80 °C

4: ammonium hydroxide / tetrahydrofuran; water / 24 h / 20 °C

5: n-butyllithium / tetrahydrofuran / 3 h / -78 °C

With ammonium hydroxide; n-butyllithium; thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201251c