(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Base Information

Chemical Name:(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one
CAS No.:850656-89-2
Molecular Formula:C₄₅H₇₂O₈Si₂
Molecular Weight:797.233
Hs Code.:

(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Synonyms:(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Suppliers and Price of (4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

There total 14 articles about (4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 850656-63-2
(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-hydroxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 850656-89-2
(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja042686r

Reference yield:

: (4aR,5aS,9aR,11aS)-2-(4-Methoxy-phenyl)-decahydro-1,3,5,9-tetraoxa-dibenzo[a,d]cycloheptene

: 850656-89-2
(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 100 percent / DIBALH / CH₂Cl₂; hexane / 6 h / 0 °C

2.1: 85 percent / I₂; PPh₃; imidazole / benzene / 0.33 h / 20 °C

3.1: 95 percent / potassium t-butoxide / tetrahydrofuran / 0.25 h / 0 °C

4.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

4.2: Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 19 h / 20 °C

5.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

5.2: 338.0 mg / aq. H₂O₂; NaOH / tetrahydrofuran / 1 h / 20 °C

6.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 20 °C

7.1: 85 percent / DDQ; aq. phosphate buffer / CH₂Cl₂ / 1.5 h / 20 °C / pH 7

8.1: 82 percent / N-methylmorpholine-N-oxide; tetra-n-propylammonium perruthenate; 4A molecular sieves / CH₂Cl₂ / 1 h / 20 °C

9.1: LHMDS; Et₃N / tetrahydrofuran / 0.5 h / -78 °C

10.1: 181.8 mg / N-methylmorpholine-N-oxide; aq. OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 21 h / 20 °C

11.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; phosphate buffer; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4 A molecular sieve; potassium tert-butylate; iodine; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol; benzene; 4.2: Suzuli-Miyaura cross-coupling;
DOI:10.1021/ja042686r

Reference yield:

: 850656-80-3
(4aS,7S,9aR)-7-(4-Methoxy-benzyloxy)-6-methylene-octahydro-1,5-dioxa-benzocycloheptene

: 850656-89-2
(4aS,6R,8S,9aR)-6-((2S,3R,5S,6R)-5-Benzyloxy-6-benzyloxymethyl-3-triethylsilanyloxy-tetrahydro-pyran-2-ylmethyl)-8-triisopropylsilanyloxy-hexahydro-1,5-dioxa-benzocyclohepten-7-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

1.2: Pd(PPh₃)4; aq. NaHCO₃ / dimethylformamide; tetrahydrofuran / 19 h / 20 °C

2.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

2.2: 338.0 mg / aq. H₂O₂; NaOH / tetrahydrofuran / 1 h / 20 °C

3.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 85 percent / DDQ; aq. phosphate buffer / CH₂Cl₂ / 1.5 h / 20 °C / pH 7

5.1: 82 percent / N-methylmorpholine-N-oxide; tetra-n-propylammonium perruthenate; 4A molecular sieves / CH₂Cl₂ / 1 h / 20 °C

6.1: LHMDS; Et₃N / tetrahydrofuran / 0.5 h / -78 °C

7.1: 181.8 mg / N-methylmorpholine-N-oxide; aq. OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 21 h / 20 °C

8.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; phosphate buffer; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4 A molecular sieve; 4-methylmorpholine N-oxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 1.2: Suzuli-Miyaura cross-coupling;
DOI:10.1021/ja042686r