3'-(o-tolyl)spiro-3-one

Base Information

Chemical Name:3'-(o-tolyl)spiro-3-one
CAS No.:76272-12-3
Molecular Formula:C₁₇H₁₃NO₃
Molecular Weight:279.295
Hs Code.:

3'-(o-tolyl)spiro<isobenzofuran-1(3H),5'(4'H)-isoxazol>-3-one

Synonyms:3'-(o-tolyl)spiro-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-(o-tolyl)spiro-3-one

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Technology Process of 3'-(o-tolyl)spiro-3-one

There total 2 articles about 3'-(o-tolyl)spiro-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3453-63-2
3-methylidenephthalide

: 74467-03-1
N-hydroxy-2-methylbenzenecarboximidoyl chloride

: 76272-12-3
3'-(o-tolyl)spiro-3-one

Guidance literature:: With triethylamine; hydroquinone; In diethyl ether; at 22 ℃; for 24h;
DOI:10.1021/jo00172a030

Reference yield:

: 577-56-0
2-acetyl-benzoic acid

: 76272-12-3
3'-(o-tolyl)spiro-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / thionyl chloride / dimethylformamide / 2 h / 60 °C

2: 65 percent / hydroquinone, Et₃N / diethyl ether / 24 h / 22 °C

With thionyl chloride; triethylamine; hydroquinone; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00172a030