1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

Base Information

Chemical Name:1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine
CAS No.:503147-12-4
Molecular Formula:C₂₀H₂₅N₅O₂
Molecular Weight:367.451
Hs Code.:

Synonyms:1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

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Chemical Property of 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

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Technology Process of 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

There total 3 articles about 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 401566-77-6
tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate

: 2863-98-1
4-hydrazinobenzonitrile hydrochloride

: 503147-12-4
1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

Guidance literature:: tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate; 4-hydrazinobenzonitrile hydrochloride; With methanesulfonic acid; In ethanol; at 20 ℃; for 3h;

With pyridine; trichlorophosphate; In ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2012.08.012

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 503147-12-4
1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-3-methyl-5-pyrazolyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: methanesulfonic acid / ethanol / 3 h / 20 °C

2.2: 18 h / 20 °C

With methanesulfonic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.08.012