(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Base Information

Chemical Name:(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester
CAS No.:202595-97-9
Molecular Formula:C₂₇H₃₃NO₇S
Molecular Weight:515.628
Hs Code.:

Synonyms:(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

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Chemical Property of (3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Chemical Property:

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Technology Process of (3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

There total 6 articles about (3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 2-Benzyloxycarbonylamino-3-[(1R,2R,5S)-2,5-bis-(toluene-4-sulfonyloxymethyl)-cyclohexyl]-propionic acid methyl ester

: 202595-97-9
(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

: (3S,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Guidance literature:: With sodium hydride; In toluene; at 95 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1021/jo9717649

Reference yield:

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 202595-97-9
(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: H₂, (Ph₃P)3RhCl / methanol; toluene / 22 h / 2585.7 Torr

3: 39 percent / NaH / toluene / 1 h / 95 °C

With Wilkinson's catalyst; hydrogen; sodium hydride; In methanol; toluene;
DOI:10.1021/jo9717649

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 202595-97-9
(3R,4aR,6S,8aR)-6-(Toluene-4-sulfonyloxymethyl)-octahydro-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / pyridine / Ambient temperature

3: H₂, (Ph₃P)3RhCl / methanol; toluene / 22 h / 2585.7 Torr

4: 39 percent / NaH / toluene / 1 h / 95 °C

With Wilkinson's catalyst; hydrogen; sodium hydride; In pyridine; methanol; toluene;
DOI:10.1021/jo9717649