2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

Base Information

Chemical Name:2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester
CAS No.:500056-27-9
Molecular Formula:C₁₈H₂₈FNO₄
Molecular Weight:341.423
Hs Code.:

Synonyms:2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

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Chemical Property of 2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

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Technology Process of 2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

There total 3 articles about 2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 500056-23-5
2-cyano-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

: 500056-27-9
2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

Guidance literature:: With hydrogen; sodium carbonate; nickel; In methanol; ethanol; at 80 ℃; for 16h; under 18751.9 Torr;
DOI:10.1002/1099-0690(200209)2002:18<3126::AID-EJOC3126<3.0.CO;2-1

Reference yield:

: 18861-57-9,50737-52-5
ethyl (E)-2-cyano-3-(4-fluorophenyl)-2-propenoate

: 500056-27-9
2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / CH₂Cl₂ / 20 °C / 11251100 Torr

2: 93 percent / p-toluenesulfonic acid / 1.5 h / Heating

3: 95 percent / H₂; Na₂CO₃ / Raney Ni / ethanol; methanol / 16 h / 80 °C / 18751.9 Torr

With hydrogen; sodium carbonate; toluene-4-sulfonic acid; nickel; In methanol; ethanol; dichloromethane;
DOI:10.1002/1099-0690(200209)2002:18<3126::AID-EJOC3126<3.0.CO;2-1

Reference yield:

: (4R,6S)-2,6-Diethoxy-4-(4-fluoro-phenyl)-5,6-dihydro-4H-pyran-3-carbonitrile

: 500056-27-9
2-aminomethyl-5,5-diethoxy-3-(4-fluoro-phenyl)-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / p-toluenesulfonic acid / 1.5 h / Heating

2: 95 percent / H₂; Na₂CO₃ / Raney Ni / ethanol; methanol / 16 h / 80 °C / 18751.9 Torr

With hydrogen; sodium carbonate; toluene-4-sulfonic acid; nickel; In methanol; ethanol;
DOI:10.1002/1099-0690(200209)2002:18<3126::AID-EJOC3126<3.0.CO;2-1