2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE
• CAS No.: 133562-34-2
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 133562-34-2.mol

Synonyms:2-AMINO-1-O-TOLYL-ETHANOL HYDROCHLORIDE;2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE;Benzenemethanol, -alpha--(aminomethyl)-2-methyl- (9CI)

Chemical Property of 2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE

Chemical Property:

• PSA: 46.25000
• LogP: 1.68740

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-1-(2-methylphenyl)ethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE

There total 9 articles about 2-AMINO-1-(2-IODO-PHENYL)-ETHANOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-1-(o-tolyl)ethan-1-ol (141303-27-7) → 2-amino-1-(o-tolyl)ethan-1-ol (133562-34-2)

Guidance literature:

2-chloro-1-(o-tolyl)ethan-1-ol; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 25 ℃; for 15h;

With water; In tetrahydrofuran; at 25 ℃; for 5h; regioselective reaction;

DOI:10.1016/j.tetlet.2012.08.013

Reference yield:

o-methylstyrene oxide (2783-26-8,86457-70-7,1195902-11-4) → (S)-2-amino-2-o-tolylethanol (1213107-41-5,1094627-41-4) + (R)-2-Amino-1-o-tolyl-ethanol (114579-92-9,133562-34-2)

Guidance literature:

o-methylstyrene oxide; With (R,R)-Jacobsen catalyst; water; In tetrahydrofuran; at 0 - 22 ℃; for 16h; Inert atmosphere;

With N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide; oxygen; In tetrahydrofuran; at 22 ℃; for 72h; Further stages; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01886

Reference yield:

1-methyl-2-vinyl-benzene (611-15-4) → 2-amino-1-(o-tolyl)ethan-1-ol (133562-34-2)

Guidance literature:

With (phthalocyaninato)iron(II); O-pivaloylhydroxylamine trifluoromethanesulfonate salt; In water; acetonitrile; at 25 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201507630

upstream raw materials:

(R)-2-(2-methylphenyl)-2-trimethylsilyloxyacetonitrile

[(p-methylphenyl)sulfonylmethyl]isonitrile

o-methylstyrene oxide

(S)-2-nitro-1-o-tolyl-ethanol

Refernces

• 1、 Solladie-Cavallo, A.,Lapitajs, G.,Buchert, P.,Klein, A.,Colonna, S.,Manfredi, A.. "Asymmetric synthesis of ephedrine analogs". . p. 357 - 364. Retrieved 1987.
• 2、 Li, Kangnan,Weber, Alexandria E.,Tseng, Luke,Malcolmson, Steven J.. "Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines". supporting information. p. 4239 - 4242. Retrieved 2017/08/23.