1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate
• CAS No.: 1013097-39-6
• Molecular Formula: C₁₇H₂₁Cl₂NO₃
• Molecular Weight: 358.265
• Mol file: 1013097-39-6.mol

Synonyms:1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Chemical Property of 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

There total 4 articles about 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1,1-dimethylethyl) 3-methyl-4-(3,4-dichlorophenyl)-5,6-dihydro-1,3(2H)-pyridinedicarboxylate (1013097-38-5) → 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate (1013097-39-6)

Guidance literature:

1-(1,1-dimethylethyl) 3-methyl-4-(3,4-dichlorophenyl)-5,6-dihydro-1,3(2H)-pyridinedicarboxylate; With lithium aluminium tetrahydride; In diethyl ether; at -20 ℃; for 0.266667h;

With water; ammonium chloride; In diethyl ether; at 20 ℃; for 0.333333h;

Reference yield:

((1S,6R/1R,6S)-6-(3,4-dichloro-phenyl)-3-aza-bicyclo[4.1.0]hept-1-yl)-methanol + di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate (1013097-39-6) + 1,1-dimethylethyl (1S,6R/1R,6S)-6-(3,4-dichlorophenyl)-1-(hydroxymethyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate + 1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-[({[(1,1-dimethylethyl)oxy]carbonyl}oxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:

In dichloromethane; at 20 - 40 ℃;

Reference yield:

1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-[({[(1,1-dimethylethyl)oxy]carbonyl}oxy)methyl]-3-azabicyclo[4.1.0]heptane-3-carboxylate → 1,1-dimethylethyl 4-(3,4-dichlorophenyl)-5-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate (1013097-39-6) + 1,1-dimethylethyl (1S,6R/1R,6S)-6-(3,4-dichlorophenyl)-1-(hydroxymethyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:

With methanol; sodium hydroxide; water; at 0 - 70 ℃; for 2.33333h; Product distribution / selectivity;

upstream raw materials:

1-(1,1-dimethylethyl) 3-methyl-4-(3,4-dichlorophenyl)-5,6-dihydro-1,3(2H)-pyridinedicarboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₂H₁₃Cl₂NO