4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

Base Information

Chemical Name:4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline
CAS No.:1469438-30-9
Molecular Formula:C₃₄H₃₁F₃N₂O₂S
Molecular Weight:588.694
Hs Code.:

Synonyms:4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

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Chemical Property of 4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

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Technology Process of 4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

There total 5 articles about 4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1185039-54-6
2-ethynyl-3,3,5-trimethyl-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

: 1469438-22-9
N-[bis(p-tolyl)methylene]-4-(trifluoromethyl)aniline

: 1469438-30-9
4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

: C₃₄H₃₁F₃N₂O₂S

Guidance literature:: With bis(trifluoromethanesulfonyl)amide; In 1,2-dichloro-ethane; at 60 ℃; for 1h; Inert atmosphere; Glovebox; Sealed tube; Microwave irradiation;
DOI:10.1055/s-0033-1339191

Reference yield:

: 2368-21-0
N-(4-methyl-benzylidene)-4-trifluoromethyl-aniline

: 1469438-30-9
4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

: C₃₄H₃₁F₃N₂O₂S

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 80 °C / Inert atmosphere

2: bis(trifluoromethanesulfonyl)amide / 1,2-dichloro-ethane / 1 h / 60 °C / Inert atmosphere; Glovebox; Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(trifluoromethanesulfonyl)amide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 1,2-dichloro-ethane; toluene;
DOI:10.1055/s-0033-1339191

Reference yield:

: 1185039-57-9
2,3-dihydro-2-[2-(triisopropylsilyl)ethynyl]-3,3,5-trimethyl-1,2-benzothiazole 1,1-dioxide

: 1469438-30-9
4,4-bis(p-tolyl)-6-(trifluoromethyl)-2-[3,3,5-trimethyl-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3,4-dihydroquinoline

: C₃₄H₃₁F₃N₂O₂S

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / Inert atmosphere

2: bis(trifluoromethanesulfonyl)amide / 1,2-dichloro-ethane / 1 h / 60 °C / Inert atmosphere; Glovebox; Sealed tube; Microwave irradiation

With tetrabutyl ammonium fluoride; bis(trifluoromethanesulfonyl)amide; In 1,2-dichloro-ethane;
DOI:10.1055/s-0033-1339191