methyl (2R,3S)-2-bromo-3-hydroxy butanoate

Base Information

• Chemical Name: methyl (2R,3S)-2-bromo-3-hydroxy butanoate
• CAS No.: 133268-19-6
• Molecular Formula: C₅H₉BrO₃
• Molecular Weight: 197.029
• Mol file: 133268-19-6.mol

Synonyms:methyl (2R,3S)-2-bromo-3-hydroxy butanoate

Chemical Property of methyl (2R,3S)-2-bromo-3-hydroxy butanoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (2R,3S)-2-bromo-3-hydroxy butanoate

There total 1 articles about methyl (2R,3S)-2-bromo-3-hydroxy butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl crotonate (623-43-8,4358-59-2,18707-60-3,130981-57-6) → methyl 2,3-dibromobutyrate (5469-24-9) + 2-Bromo-3-hydroxy-butyric acid methyl ester (26708-37-2,28423-53-2,133268-19-6,138877-00-6,144938-85-2) + 3-Bromo-2-hydroxy-butyric acid methyl ester

Guidance literature:

With bromine; In water; at 30 ℃; Rate constant; Thermodynamic data; Product distribution; other temperatures (22, 38, 46, 54 deg C), ΔH^*, ΔS^*, ΔG^*;

DOI:10.1246/bcsj.57.1394

Reference yield: 85.0%

methyl (2R,3S)-2-bromo-3-hydroxy butanoate (133268-19-6) → (S)-3-hydroxybutyric acid methyl ester (53562-86-0)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 4h;

DOI:10.1080/00397919108021588

upstream raw materials:

methyl crotonate

Downstream raw materials:

(S)-3-hydroxybutyric acid methyl ester

Refernces