(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

Base Information

Chemical Name:(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one
CAS No.:105018-81-3
Molecular Formula:C₁₄H₂₅NO₄
Molecular Weight:271.357
Hs Code.:

(5S,1'S)-5-<1'-<N-(tert-Butoxycarbonyl)amino>-3'-methylbutyl>dihydrofuran-2(3H)-one

Synonyms:(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

Suppliers and Price of (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

There total 1 articles about (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: 136401-22-4
(1-methoxy-3-methylbutyl)carbamic acid tert-butyl ester

: 105018-81-3
(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

: 105018-83-5
(5R,1'S)-5-[1'[(tert-butoxycarbonyl)amino]-3'-methylbutyl]-dihydrofuran-2(3H)-one

Guidance literature:: With sodium tetrahydroborate; boron trifluoride diethyl etherate; nickel dichloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, a) -40 deg C, 4 h, b) -15 deg C, 12 h; 2.) CH₃OH;
DOI:10.1016/S0040-4039(00)79378-6

Reference yield:

: 105018-81-3
(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

: (2R,4S,5S)-5-Amino-4-hydroxy-2-isobutyl-7-methyl-octanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / -78 °C

2.1: aq. LiOH / tetrahydrofuran / 8 h / 23 °C

3.1: imidazole / dimethylformamide / 24 h

4.1: EDC; HOBt; iPr₂NEt / dimethylformamide; CH₂Cl₂ / 0 - 23 °C

5.1: nBu₄NF / tetrahydrofuran / 23 °C

6.1: TFA / CH₂Cl₂ / 23 °C

With 1H-imidazole; lithium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101803

Reference yield:

: 105018-81-3
(5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one

: 527674-73-3
tert-butyl (1S,2S,4R)-5-{[(1S)-2-(benzylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-isobutyl-4-methyl-5-oxopentylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: aq. LiOH / tetrahydrofuran / 8 h / 23 °C

3.1: imidazole / dimethylformamide / 24 h

4.1: EDC; HOBt; iPr₂NEt / dimethylformamide; CH₂Cl₂ / 0 - 23 °C

5.1: nBu₄NF / tetrahydrofuran / 23 °C

With 1H-imidazole; lithium hydroxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0101803