N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

Base Information

Chemical Name:N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester
CAS No.:1477460-73-3
Molecular Formula:C₄₉H₅₆N₄O₁₈
Molecular Weight:989
Hs Code.:

N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

Synonyms:N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

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Chemical Property of N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

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Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

There total 2 articles about N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 878483-02-4
N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-(2-azido-2-deoxy-4,6-O-benzylidene-α-D-galactopyranosyl)-L-serine tert-butyl ester

: 86520-63-0
2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate

: 1477460-73-3
N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

Guidance literature:: N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-(2-azido-2-deoxy-4,6-O-benzylidene-α-D-galactopyranosyl)-L-serine tert-butyl ester; 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Molecular sieve;

With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at -20 ℃; for 1h; Molecular sieve;
DOI:10.1021/ol402845e

Reference yield:

: 1257307-76-8
C₂₈H₃₄N₄O₉

: 1477460-73-3
N-[(9H-fluoren-9-yl)-methoxycarbonyl]-O-[O-(2'',3'',4''-6''-tetra-O-acetyl-β-D-galactopyranosyl)-(1''-3)-(2-azido-4O,6O-benzylidene-2-deoxy-α-D-galactopyranosyl)]-L-serine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: 1,2-dichloro-ethane / 0.5 h / 20 °C / Molecular sieve

2.2: 1 h / -20 °C / Molecular sieve

With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ol402845e