3,5-Difluoro-DL-phenylalanine

Base Information

Chemical Name:3,5-Difluoro-DL-phenylalanine
CAS No.:32133-37-2
Molecular Formula:C9H9F2NO2
Molecular Weight:201.173
Hs Code.:2922499990
European Community (EC) Number:670-833-8
DSSTox Substance ID:DTXSID10371798
Mol file:32133-37-2.mol

Synonyms:3,5-difluoro-dl-phenylalanine;32133-37-2;DL-3,5-Difluorophenylalanine;2-amino-3-(3,5-difluorophenyl)propanoic Acid;3,5-difluorophenylalanine;MFCD00061308;3,5-Difluoro-L-phenylaniline;D-3,5-Difluorophenylalanine;SCHEMBL188320;DTXSID10371798;QFGMPXZFCIHYIR-UHFFFAOYSA-N;CCG-47323;DL-3,5-Difluorophenylalanine, 97%;AKOS015915736;AKOS032963164;AB02433;AB09417;AB09419;AC-9902;CS-W021816;HY-W041076;PS-6487;ACETOPHENONE-2,3,4,5,6-D5;SY044825;FT-0614605;FT-0654122;FT-0658768;2-Amino-3-(3,5-difluorophenyl)propionic acid;A50353;2-amino-3-(3,5-difluoro-phenyl)-propionic acid;EN300-1858212;A818536;A821165;J-018644;SR-01000636947-1;2-azanyl-3-[3,5-bis(fluoranyl)phenyl]propanoic acid

Suppliers and Price of 3,5-Difluoro-DL-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Difluoro-DL-phenylalanine
250mg
$ 75.00

SynQuest Laboratories
3,5-Difluoro-DL-phenylalanine 97%
5 g
$ 495.00

SynQuest Laboratories
3,5-Difluoro-DL-phenylalanine 97%
1 g
$ 128.00

SynQuest Laboratories
3,5-Difluoro-DL-phenylalanine 97%
250 mg
$ 56.00

Sigma-Aldrich
DL-3,5-Difluorophenylalanine 97%
500mg
$ 42.10

Matrix Scientific
DL-3,5-Difluorophenylalanine 97%
1g
$ 155.00

Matrix Scientific
3-Amino-3-(3,5-difluorophenyl)propanoic acid
500mg
$ 126.00

Matrix Scientific
DL-3,5-Difluorophenylalanine 97%
5g
$ 425.00

Crysdot
3,5-Difluoro-DL-phenylalanine 97%
10g
$ 252.00

Chemenu
3,5-Difluoro-DL-phenylalanine 97%
10g
$ 237.00

Total 34 raw suppliers

Chemical Property of 3,5-Difluoro-DL-phenylalanine

Chemical Property:

Vapor Pressure:0.00065mmHg at 25°C
Melting Point:269.5-273.5 °C(lit.)
Refractive Index:1.534
Boiling Point:295.1 °C at 760 mmHg
PKA:2.13±0.20(Predicted)
Flash Point:132.3 °C
PSA：63.32000
Density:1.379 g/cm³
LogP:1.61950
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:201.06013485
Heavy Atom Count:14
Complexity:203

Purity/Quality:

97% ^*data from raw suppliers

3,5-Difluoro-DL-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C=C1F)F)CC(C(=O)O)N

Technology Process of 3,5-Difluoro-DL-phenylalanine

There total 3 articles about 3,5-Difluoro-DL-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 266360-46-7
2-acetylamino-2-(3,5-difluoro-benzyl)-malonic acid diethyl ester

: 32133-37-2,266360-63-8
rac-3,5-difluorophenylalanine

Guidance literature:: With hydrogen bromide; at 100 ℃; for 4h;
DOI:10.1002/1521-3765(20011001)7:19<4296::AID-CHEM4296>3.0.CO;2-2

Reference yield:

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 32133-37-2,266360-63-8
rac-3,5-difluorophenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaOEt / ethanol / 0.17 h

1.2: ethanol / 12 h / 80 °C

2.1: aq. HBr / 4 h / 100 °C

With hydrogen bromide; sodium ethanolate; In ethanol;
DOI:10.1002/1521-3765(20011001)7:19<4296::AID-CHEM4296>3.0.CO;2-2