1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

Base Information

Chemical Name:1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate
CAS No.:142350-49-0
Molecular Formula:C₄₃H₅₇Cl₃NO₁₁P
Molecular Weight:901.258
Hs Code.:

1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

Synonyms:1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

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Chemical Property of 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

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Technology Process of 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

There total 13 articles about 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 257887-95-9
1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-glyceryl 2,2,2-trichloro-tert-butyl 1-carbomethoxy-1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphite

: 142350-49-0
1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

Guidance literature:: With dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 2h;
DOI:10.1021/jo990739v

Reference yield:

: 1191-25-9
6-Hydroxyhexanoic acid

: 142350-49-0
1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: HCl

2.1: 89 percent / BF₃*OEt₂ / CH₂Cl₂ / 4 h

3.1: 69 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / 20 °C

4.1: 90 percent / molecular sieves 3A / acetonitrile / 36 h / 20 °C

5.1: 75 percent / potassium carbonate / methanol / 0.5 h / 0 °C

6.1: diisopropylethylamine / tetrahydrofuran / 0.25 h / -78 °C

6.2: 45 percent / tetrahydrofuran / -78 - 20 °C

7.1: 92 percent / hydrogen peroxide / H₂O; CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; 3 A molecular sieve; boron trifluoride diethyl etherate; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1.1: Esterification / 2.1: Ring cleavage / 3.1: Addition / 4.1: Acetoxylation / 5.1: Deacetylation / 6.1: phosphitylation; phosphorylation / 6.2: coupling; phosphorylation; phosphitylation / 7.1: Oxidation;
DOI:10.1021/jo990739v

Reference yield:

: 4547-43-7
methyl 6-hydroxycaproate

: 142350-49-0
1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-3-glyceryl 2,2,2-trichloro-tert-butyl 1-N-triphenylmethylamino-1-carbomethoxy-2-propyl phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / BF₃*OEt₂ / CH₂Cl₂ / 4 h

2.1: 69 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / 20 °C

3.1: 90 percent / molecular sieves 3A / acetonitrile / 36 h / 20 °C

4.1: 75 percent / potassium carbonate / methanol / 0.5 h / 0 °C

5.1: diisopropylethylamine / tetrahydrofuran / 0.25 h / -78 °C

5.2: 45 percent / tetrahydrofuran / -78 - 20 °C

6.1: 92 percent / hydrogen peroxide / H₂O; CH₂Cl₂ / 2 h / 20 °C

With 3 A molecular sieve; boron trifluoride diethyl etherate; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1.1: Ring cleavage / 2.1: Addition / 3.1: Acetoxylation / 4.1: Deacetylation / 5.1: phosphitylation; phosphorylation / 5.2: coupling; phosphorylation; phosphitylation / 6.1: Oxidation;
DOI:10.1021/jo990739v