(S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene

Base Information

• Chemical Name: (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene
• CAS No.: 1383735-61-2
• Molecular Formula: C₁₄H₁₆FN₃
• Molecular Weight: 245.3
• Mol file: 1383735-61-2.mol

Synonyms:(S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene

Chemical Property of (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene

There total 6 articles about (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17BrFN3 (1383735-13-4) → (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene (1383735-61-2)

Guidance literature:

With sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In toluene; at 100 ℃; for 18h;

Reference yield:

C14H14BrFN2O (1383735-09-8) → (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene (1383735-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1: titanium(IV) isopropylate / tetrahydrofuran / 18 h / Reflux

2: L-Selectride / tetrahydrofuran / 1 h / -78 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 1 h

4: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / toluene / 18 h / 100 °C

With titanium(IV) isopropylate; hydrogenchloride; L-Selectride; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;

Reference yield:

C18H23BrFN3OS (1383735-10-1) → (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene (1383735-61-2)

Guidance literature:

Multi-step reaction with 3 steps

1: L-Selectride / tetrahydrofuran / 1 h / -78 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 1 h

3: sodium t-butanolate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / toluene / 18 h / 100 °C

With hydrogenchloride; L-Selectride; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;

upstream raw materials:

C₁₄H₁₄BrFN₂O

C₁₈H₂₃BrFN₃OS

C₁₈H₂₅BrFN₃OS

C₁₄H₁₇BrFN₃