N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

Base Information

Chemical Name:N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide
CAS No.:847549-20-6
Molecular Formula:C₂₇H₃₂BrN₃O₅S
Molecular Weight:590.538
Hs Code.:

<i>N</i>-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1<i>H</i>-indol-3-yl]-ethyl}-<i>N</i>-methyl-4-nitro-benzenesulfonamide

Synonyms:N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

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Chemical Property of N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

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Technology Process of N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

There total 5 articles about N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 847549-19-3
N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

: 870-63-3
prenyl bromide

: 847549-20-6
N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ol047532v

Reference yield:

: 847549-17-1
N-[2-(6-bromo-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

: 847549-20-6
N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / N-bromosuccinimide; H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / 20 °C

2: 74 percent / cesium carbonate / CH₂Cl₂ / 24 h / 20 °C

3: 83 percent / sodium hydride / tetrahydrofuran / 6 h / 20 °C

With N-Bromosuccinimide; water; sodium hydride; caesium carbonate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol047532v

Reference yield:

: 847549-18-2
N-[2-(3,6-dibromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

: 847549-20-6
N-{2-[6-bromo-3-(1,1-dimethyl-allyl)-1-(3-methyl-but-2-enyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-ethyl}-N-methyl-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / cesium carbonate / CH₂Cl₂ / 24 h / 20 °C

2: 83 percent / sodium hydride / tetrahydrofuran / 6 h / 20 °C

With sodium hydride; caesium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol047532v