(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

Base Information

Chemical Name:(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene
CAS No.:215173-34-5
Molecular Formula:C₂₀H₂₄O₂S
Molecular Weight:328.475
Hs Code.:

Synonyms:(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

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Technology Process of (2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

There total 2 articles about (2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3112-85-4
methylphenylsulfonate

: 195257-52-4
(2R,3E)-5-bromo-2,4-dimethyl-3-pentenylbenzene

: 215173-34-5
(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

Guidance literature:: With potassium hydride; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1021/jo011157s

Reference yield:

: 215173-33-4
(4R)-2,4-dimethyl-5-phenyl-1-penten-3-ol

: 215173-34-5
(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: MsCl; Et₃N / CH₂Cl₂ / 1 h / 20 °C

1.2: 81 percent / NaBr; 18-crown-6 ether / butan-2-one / 6 h / Heating

2.1: 89 percent / KH / tetrahydrofuran / 10 h / 20 °C

With potassium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo011157s

Reference yield:

: 215173-34-5
(2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene

: 440641-10-1
(5R,8R,9S)-8-tert-butyldiphenylsiloxymethyl-9-methoxycarbonyl-9-trimethylsiloxy-1,7-dioxaspiro[4.4]nonane-2,6-dione

: 215173-36-7
(1S,3R,4S,5R)-1-[(3E,5R)-3,5-dimethyl-6-phenyl-3-hexenyl]-4-hydroxy-3-hydroxymethyl-4,5-bis(methoxycarbonyl)-2,8-dioxabicyclo[3.2.1]octane

: (5R,8R,9S)-2-[(3E,5R)-3,5-dimethyl-6-phenyl-3-hexenyl]-9-hydroxy-8-(hydroxymethyl)-2-methoxy-9-methoxycarbonyl-1,7-dioxaspiro[4.4]nonan-6-one

Guidance literature:: (2R,3E)-2,4-dimethyl-6-phenylsulfonyl-3-hexenylbenzene; (5R,8R,9S)-8-tert-butyldiphenylsiloxymethyl-9-methoxycarbonyl-9-trimethylsiloxy-1,7-dioxaspiro[4.4]nonane-2,6-dione; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2h;

With aluminum amalgam; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; at 20 ℃; for 3h;

With sulfuric acid; In methanol; at 20 ℃; for 40h;
DOI:10.1021/jo011157s