glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Base Information

Chemical Name:glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester
CAS No.:1056010-85-5
Molecular Formula:C₂₄H₂₈ClN₅O₅
Molecular Weight:501.97
Hs Code.:

Synonyms:glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

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Chemical Property of glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Chemical Property:

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Technology Process of glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

There total 6 articles about glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1056010-85-5
glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 16 h / 80 °C

2.1: methanol; ammonia / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 1 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; ammonia; caesium carbonate; trifluoroacetic acid; In dichloromethane; ISOPROPYLAMIDE; isopropyl alcohol;

Reference yield:

: glycine, N-[[4-chloro-2-[[6-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propoxy]-7-methoxy-4-quinazolinyl]amino]phenyl]acetyl]-, ethyl ester

: 1056010-85-5
glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 807640-16-0
glycine, N-[ (4-chloro-2-nitrophenyl) acetyl]-, ethyl ester

: 1056010-85-5
glycine, N-[[2-[[6-(3-aminopropoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran

2.1: isopropyl alcohol / 16 h / 80 °C

3.1: methanol; ammonia / 20 °C

4.1: caesium carbonate / ISOPROPYLAMIDE / 1 h / 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With thiophene; methanol; ammonia; hydrogen; caesium carbonate; trifluoroacetic acid; platinum on activated charcoal; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; isopropyl alcohol;