2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide

Base Information

• Chemical Name: 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide
• CAS No.: 872408-97-4
• Molecular Formula: C₂₀H₂₀Br₂ClN₃O₂S
• Molecular Weight: 561.725

Synonyms:2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide

Chemical Property of 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide

Chemical Property:

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Technology Process of 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide

There total 2 articles about 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-bromo-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thien-4-yl)acetamide (872408-08-7) + 1-(2-chloro-benzyl)-piperazine (17532-19-3) → 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide (872408-97-4)

Guidance literature:

With potassium carbonate; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2005.07.009

Reference yield:

1,3-dibromo-4-oxo-5,6-dihydro-4H-cyclopentathien-6-ylammonium chloride → 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide (872408-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / triethylamine / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 77 percent / potassium carbonate / 12 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2005.07.009

Reference yield: 75.0%

2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide (872408-97-4) → 2-[4-(2-chloro-benzyl)-piperazin-1-yl]-N-(1,3-dibromo-6-hydroxyimino-5,6-dihydro-4H-cyclopenta[c]thiophen-4-yl)-acetamide

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; for 3h; Heating;

DOI:10.1016/j.ejmech.2005.07.009

upstream raw materials:

2-bromo-N-(1,3-dibromo-6-oxo-5,6-dihydro-4H-cyclopenta[c]thien-4-yl)acetamide

1-(2-chloro-benzyl)-piperazine

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