1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

Base Information

• Chemical Name: 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane
• CAS No.: 220871-52-3
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 220871-52-3.mol

Synonyms:1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

Chemical Property of 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

There total 18 articles about 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

((S)-1-benzylallyl)carbamic acid tert-butyl ester (103127-52-2,107202-43-7) → 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane (220871-52-3)

Guidance literature:

With Oxone; sodium hydrogencarbonate; In water; ethyl acetate; acetone; for 17h;

DOI:10.1021/op100174j

Reference yield: 67.0%

methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester (425622-87-3) → 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane (220871-52-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(01)01152-8

Reference yield: 26.0%

(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate (102123-74-0) → tert-butyl ((2S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate (1229623-13-5) + 1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane (220871-52-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; dichloromethane; at 0 ℃; for 24h;

DOI:10.1021/acs.oprd.0c00120

upstream raw materials:

((S)-1-benzylallyl)carbamic acid tert-butyl ester

methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester

di-tert-butyl dicarbonate

phenylmagnesium bromide

Downstream raw materials:

tert-butyl (2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl-carbamate

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(2R,3S)-3-amino-1-((S)-6-neopentylspiro[chroman-2,1'-cyclobutane]-4-ylamino)-4-phenylbutan-2-ol