(S)-2-hexanedioic acid γ-methyl ester

Base Information

• Chemical Name: (S)-2-hexanedioic acid γ-methyl ester
• CAS No.: 147698-07-5
• Molecular Formula: C₂₆H₂₅NO₄
• Molecular Weight: 415.489
• Mol file: 147698-07-5.mol

Synonyms:(S)-2-hexanedioic acid γ-methyl ester

Chemical Property of (S)-2-hexanedioic acid γ-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-hexanedioic acid γ-methyl ester

There total 6 articles about (S)-2-hexanedioic acid γ-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-tert-Butyl 6-methyl (S)-2-[N-(9-phenylfluoren-9-yl)amino]hexandioate (147698-06-4) → (S)-2-hexanedioic acid γ-methyl ester (147698-07-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 24h; Ambient temperature;

DOI:10.1021/jo00061a006

Reference yield:

1-tert-Butyl 6-methyl (S)-2-hex-4-enedioate (147698-04-2) → (S)-2-hexanedioic acid γ-methyl ester (147698-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂, HCl / 10percent Pd/C / ethyl acetate / a) 16 h, b) r.t., 24 h

2: 77 percent / propylene oxide / ethanol / 6 h / Heating

3: 1.) trimethylsilyl chloride, 2.) Et₃N, Pb(NO₃)2 / 1.) CH₂Cl₂, reflux, 2 h, 2.) CH₂Cl₂, r.t., 96 h

With hydrogenchloride; chloro-trimethyl-silane; lead(II) nitrate; hydrogen; triethylamine; methyloxirane; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jo00061a006

Reference yield:

9-bromo-9-phenyl-9H-fluorene (55135-66-5) → (S)-2-hexanedioic acid γ-methyl ester (147698-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / K₃PO₄ / nitromethane / 72 h / Ambient temperature

2: 89 percent / HCl / ethyl acetate / 24 h / Ambient temperature

With hydrogenchloride; potassium phosphate; In nitromethane; ethyl acetate;

DOI:10.1021/jo00061a006

upstream raw materials:

9-bromo-9-phenyl-9H-fluorene

1-tert-Butyl 6-methyl (S)-2-[N-(9-phenylfluoren-9-yl)amino]hexandioate

1-tert-Butyl 6-methyl (S)-2-hex-4-enedioate

Downstream raw materials:

(S)-3--1-(hydroxymethyl)cyclopentene

(S)-3--(methoxycarbonyl)cyclopentene

(1S,3R/S)-1-[N-(9-Phenylfluoren-9-yl)amino]-2-oxo-3-(methoxycarbonyl)cyclopentane

(1S,4R)-4-tert-Butoxycarbamoyl-1-methoxycarbonylcyclopentane