N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide

Base Information

• Chemical Name: N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide
• CAS No.: 396728-19-1
• Molecular Formula: C₆₃H₉₈N₄O₅
• Molecular Weight: 991.495
• Mol file: 396728-19-1.mol

Synonyms:N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide

Chemical Property of N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide

There total 4 articles about N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

2-dodecyloxy-3-octadecyloxy-propylamine (396728-03-3) + N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine pentafluorophenyl ester (396728-17-9) → N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide (396728-19-1)

Guidance literature:

In tetrahydrofuran; at 85 ℃;

DOI:10.1021/jm010918g

Reference yield:

1-dodecyl alcohol (112-53-8) → N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide (396728-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / CH₂Cl₂ / 0 °C

1.2: 96 percent / CH₂Cl₂ / 2 h / 20 °C

2.1: 79.8 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂ / 78 h / Heating

3.1: 91.8 percent / hydrazine monohydrate / ethanol / 18 h / Heating

4.1: 76.9 percent / tetrahydrofuran / 85 °C

With pyridine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm010918g

Reference yield:

lauryl triflate (75618-27-8) → N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine(2-lauryloxy-3-stearyloxy)propylamide (396728-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 79.8 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂ / 78 h / Heating

2: 91.8 percent / hydrazine monohydrate / ethanol / 18 h / Heating

3: 76.9 percent / tetrahydrofuran / 85 °C

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm010918g

upstream raw materials:

2-dodecyloxy-3-octadecyloxy-propylamine

N-α-tert-butyloxycarbonyl-N-im-trityl-L-histidine pentafluorophenyl ester

1-dodecyl alcohol

lauryl triflate