5-Chloro-2-(3,5-dimethoxyphenyl)thiazole

Base Information

• Chemical Name: 5-Chloro-2-(3,5-dimethoxyphenyl)thiazole
• CAS No.: 1207426-83-2
• Molecular Formula: C₁₁H₁₀ClNO₂S
• Molecular Weight: 255.725
• DSSTox Substance ID: DTXSID50695081
• Wikidata: Q82624089

Synonyms:5-CHLORO-2-(3,5-DIMETHOXYPHENYL)THIAZOLE;1207426-83-2;5-chloro-2-(3,5-dimethoxyphenyl)-1,3-thiazole;DTXSID50695081;CS-0200045;A927512

Chemical Property of 5-Chloro-2-(3,5-dimethoxyphenyl)thiazole

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 255.0120774
• Heavy Atom Count: 16
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-2-(3,5-dimethoxyphenyl)thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)C2=NC=C(S2)Cl)OC

Technology Process of 5-Chloro-2-(3,5-dimethoxyphenyl)thiazole

There total 1 articles about 5-Chloro-2-(3,5-dimethoxyphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(3,5-dimethoxyphenyl)thiazole (1186493-24-2) → 5-chloro-2-(3,5-dimethoxyphenyl)thiazole (1207426-83-2)

Guidance literature:

2-(3,5-dimethoxyphenyl)thiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With hexachloroethane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

DOI:10.1021/jo902515z

Reference yield: 65.0%

para-bromotoluene (106-38-7) + 5-chloro-2-(3,5-dimethoxyphenyl)thiazole (1207426-83-2) → 5-chloro-2-(3,5-dimethoxyphenyl)-4-(p-tolyl)thiazole (1207426-87-6)

Guidance literature:

With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate; Trimethylacetic acid; In 1,3,5-trimethyl-benzene; at 140 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo902515z

Reference yield: 62.0%

Ethyl 4-bromobenzoate (5798-75-4) + 5-chloro-2-(3,5-dimethoxyphenyl)thiazole (1207426-83-2) → ethyl 4-(5-chloro-2-(3,5-dimethoxyphenyl)thiazol-4-yl)benzoate (1207426-88-7)

Guidance literature:

With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate; Trimethylacetic acid; In 1,3,5-trimethyl-benzene; at 140 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo902515z

upstream raw materials:

2-(3,5-dimethoxyphenyl)thiazole

Downstream raw materials:

ethyl 4-(5-chloro-2-(3,5-dimethoxyphenyl)thiazol-4-yl)benzoate

5-chloro-2-(3,5-dimethoxyphenyl)-4-(p-tolyl)thiazole

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