8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione

Base Information

• Chemical Name: 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione
• CAS No.: 1534330-47-6
• Molecular Formula: C₂₀H₂₁N₅O₂
• Molecular Weight: 363.419

Synonyms:8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione

Chemical Property of 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione

Chemical Property:

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Technology Process of 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione

There total 2 articles about 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

8,8-dimethyl-2,10-dioxo-11-phenyl-1,2,3,4,6,7,8,9,10,11-decahydropyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazolin-12-ium chloride (1534330-34-1) → 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione (1534330-47-6)

Guidance literature:

With sodium carbonate; In water; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2013.11.090

Reference yield:

C20H22ClN5O2 → 8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione (1534330-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; acetonitrile / 4 h / 80 - 90 °C

2: sodium carbonate / water / 1 h / 20 °C

With sodium carbonate; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2013.11.090

Reference yield: 50.0%

8,8-dimethyl-11-phenyl-3,4,7,11-tetrahydro-8H-pyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazoline-2,10(1H,9H)-dione (1534330-47-6) → 2-amino-6,6-dimethyl-9-phenyl-5,6,7,9-tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one (872410-93-0)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Reflux;

DOI:10.1016/j.tet.2013.11.090

upstream raw materials:

8,8-dimethyl-2,10-dioxo-11-phenyl-1,2,3,4,6,7,8,9,10,11-decahydropyrimido[2',1':3,4][1,2,4]triazolo[5,1-b]quinazolin-12-ium chloride

Downstream raw materials:

2-amino-6,6-dimethyl-9-phenyl-5,6,7,9-tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one

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