1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one
CAS No.:1571034-57-5
Molecular Formula:C₂₂H₁₄BrF₃N₂O₃
Molecular Weight:491.264
Hs Code.:

Synonyms:1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

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Chemical Property of 1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

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Technology Process of 1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

There total 7 articles about 1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1571034-54-2
1-(3-bromobenzyl)-5-(3-(((4-methoxybenzyl)oxy)imino)-3-(4-(trifluoromethoxy)phenyl)propanoyl)pyridin-2(1H)-one

: 1571034-57-5
1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 3h;

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 1571034-57-5
1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; lithium chloride / N,N-dimethyl-formamide / 18 h / 65 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 6 h / -78 °C

3.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 50 °C

With n-butyllithium; caesium carbonate; Dess-Martin periodane; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 85013-98-5
1-[4-(trifluoromethoxy)phenyl]ethan-1-one

: 1571034-57-5
1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 6 h / -78 °C

3.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 50 °C

With n-butyllithium; Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; pyridine; hexane; dichloromethane;