trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

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Chemical Name:trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate
CAS No.:1352737-10-0
Molecular Formula:C₂₄H₃₈N₄O₃
Molecular Weight:430.591
Hs Code.:

Synonyms:trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

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Chemical Property of trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

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Technology Process of trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

There total 2 articles about trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 1352737-09-7
4-(piperazin-1-yl)-2,3-dihydrofuro[3,2-c]pyridine

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 1352737-10-0
trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

Guidance literature:: 4-(piperazin-1-yl)-2,3-dihydrofuro[3,2-c]pyridine; trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde; With triethylamine; In methanol; dichloromethane; at 20 ℃; for 0.5h;

With methanol; sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 81078-84-4
4-(1-piperazinyl)furo<3,2-c>pyridine

: 1352737-10-0
trans-tert-butyl (4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; acetic acid / 5%-palladium/activated carbon / methanol / 48 h / 20 °C

2.1: triethylamine / dichloromethane; methanol / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With hydrogen; acetic acid; triethylamine; 5%-palladium/activated carbon; In methanol; dichloromethane;