4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

Base Information

Chemical Name:4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid
CAS No.:1332848-99-3
Molecular Formula:C₃₄H₃₄O₁₀
Molecular Weight:602.638
Hs Code.:

Synonyms:4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

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Chemical Property of 4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

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Technology Process of 4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

There total 16 articles about 4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1332849-13-4
C₃₈H₄₂O₁₀

: 1332848-99-3
4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

Guidance literature:: C₃₈H₄₂O₁₀; With potassium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 65.5h;

With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/chem.201101015

Reference yield: 82.0%

: 4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzaldehyde

: 1332848-99-3
4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

Guidance literature:: With oxone; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/cphc.201600234

Reference yield:

: 50586-80-6,58320-73-3
toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

: 1332848-99-3
4,4’-({2,5-bis[2-(2-methoxyethoxy)ethoxy]-1,4-phenylene}bis(ethyne-2,1-diyl))dibenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / Reflux; Inert atmosphere

1.2: 72 h / Reflux; Inert atmosphere

2.1: potassium iodate; sulfuric acid; acetic acid; iodine / water / 48 h / Reflux; Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 24 h / Inert atmosphere

4.1: oxone / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium iodate; copper(l) iodide; oxone; sulfuric acid; iodine; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 1.1: |Williamson Ether Synthesis / 1.2: |Williamson Ether Synthesis / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1002/cphc.201600234