(R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol

Base Information

• Chemical Name: (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol
• CAS No.: 262586-88-9
• Molecular Formula: C₁₆H₃₀O₂Si
• Molecular Weight: 282.498
• Mol file: 262586-88-9.mol

Synonyms:(R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol

Chemical Property of (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol

There total 2 articles about (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-Butyldimethyl(prop-2-ynyloxy)silane (76782-82-6) + cyclohexanecarbaldehyde (2043-61-0) → (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol (262586-88-9)

Guidance literature:

tert-Butyldimethyl(prop-2-ynyloxy)silane; With zinc trifluoromethanesulfonate; triethylamine; (1S,2S)-2-N,N-dimethylamino-1-(p-nitrophenyl)-3-(tert-butyldimethylsilyloxy)propan-1-ol; In toluene; for 0.25h;

cyclohexanecarbaldehyde; In toluene; at 25 ℃; for 2h; Further stages.;

DOI:10.1039/b203984b

Reference yield:

tert-Butyldimethyl(prop-2-ynyloxy)silane (76782-82-6) + cyclohexanecarbaldehyde (2043-61-0) → (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol (262586-88-9) + 4-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-but-2-yn-1-ol

Guidance literature:

tert-Butyldimethyl(prop-2-ynyloxy)silane; With zinc trifluoromethanesulfonate; (+)-N-methylephedrine; triethylamine; In toluene; at 23 ℃; for 0.25h;

cyclohexanecarbaldehyde; In toluene; at 60 ℃; for 5h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja016378u

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (R)-1-cyclohexyl-4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol (262586-88-9) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-4-(tert-butyl-dimethyl-silanyloxy)-1-cyclohexyl-but-2-ynyl ester

Guidance literature:

With pyridine; dmap; In dichloromethane; at 23 ℃; for 14h;

DOI:10.1021/ja993838z

upstream raw materials:

tert-Butyldimethyl(prop-2-ynyloxy)silane

cyclohexanecarbaldehyde