3-(2-bromophenyl)-2-cyclopentylpropionic acid

Base Information

Chemical Name:3-(2-bromophenyl)-2-cyclopentylpropionic acid
CAS No.:1217864-49-7
Molecular Formula:C₁₄H₁₇BrO₂
Molecular Weight:297.192
Hs Code.:

Synonyms:3-(2-bromophenyl)-2-cyclopentylpropionic acid

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Chemical Property of 3-(2-bromophenyl)-2-cyclopentylpropionic acid

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Technology Process of 3-(2-bromophenyl)-2-cyclopentylpropionic acid

There total 1 articles about 3-(2-bromophenyl)-2-cyclopentylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 18928-91-1
diethyl 2-cyclopentylmalonate

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 1217864-49-7
3-(2-bromophenyl)-2-cyclopentylpropionic acid

Guidance literature:: diethyl 2-cyclopentylmalonate; With sodium hydride; In tetrahydrofuran; mineral oil; for 2h; Inert atmosphere;

1-Bromo-2-bromomethyl-benzene; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h; Inert atmosphere;

With potassium tert-butylate; In tetrahydrofuran; water; mineral oil; for 16h; Reflux; Inert atmosphere;
DOI:10.1007/s11172-008-0217-2

Reference yield:

: 1217864-49-7
3-(2-bromophenyl)-2-cyclopentylpropionic acid

: C₁₄H₁₆BrClO

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h; Reflux; Inert atmosphere;
DOI:10.1007/s11172-008-0217-2

Reference yield:

: 1217864-49-7
3-(2-bromophenyl)-2-cyclopentylpropionic acid

: 1217864-47-5
2-cyclopentyl-7-phenylindene

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Reflux; Inert atmosphere

2: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 8 h / Reflux; Inert atmosphere

4: lithium aluminium tetrahydride / diethyl ether / -40 - 20 °C / Inert atmosphere

5: toluene-4-sulfonic acid / benzene / 2 h / Inert atmosphere; Reflux

With aluminum (III) chloride; lithium aluminium tetrahydride; thionyl chloride; palladium diacetate; sodium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; triphenylphosphine; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; benzene; 2: Friedel-Crafts reaction / 3: Suzuki coupling;
DOI:10.1007/s11172-008-0217-2