Technology Process of methyl (2E,4E,6E,8E)-11-{[(tert-butyldiphenyl)silyl]oxy}-4,6,8-trimethylundeca-2,4,6,8-tetraenoate
There total 7 articles about methyl (2E,4E,6E,8E)-11-{[(tert-butyldiphenyl)silyl]oxy}-4,6,8-trimethylundeca-2,4,6,8-tetraenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate tribasic trihydrate; N,N-diisopropyl 2-dicyclohexylphosphino-4-(2',6'-dimethylphenyl)benzamide; water; palladium diacetate;
In
tetrahydrofuran;
at 35 ℃;
for 18h;
Reagent/catalyst;
Solvent;
Temperature;
Time;
Inert atmosphere;
DOI:10.1002/ejoc.201301484
- Guidance literature:
-
tert-butyl[(pent-3-ynyl)oxy]diphenylsilane;
With
(4S,6S)-{2,2-di-tert-butyl-6-ethyl[1,3,2]dioxasilinan-4-yl}acetaldehyde; bis(pinacol)diborane; copper(l) chloride; sodium t-butanolate;
In
methanol; toluene;
at 20 ℃;
for 3h;
Glovebox;
Inert atmosphere;
methyl (2E,4E,6E)-7-bromo-4,6-dimethylhepta-2,4,6-trienoate;
With
potassium phosphate tribasic trihydrate; N,N-diisopropyl 2-dicyclohexylphosphino-4-(2',6'-dimethylphenyl)benzamide; palladium diacetate;
In
tetrahydrofuran; water;
at 35 ℃;
for 18h;
Reagent/catalyst;
Solvent;
Temperature;
Sealed tube;
Inert atmosphere;
DOI:10.1002/ejoc.201301484
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / 0 °C
1.2: 1 h / 20 °C
2.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -78 °C
3.2: 2 h / -78 °C
4.1: palladium diacetate; potassium phosphate tribasic trihydrate; N,N-diisopropyl 2-dicyclohexylphosphino-4-(2',6'-dimethylphenyl)benzamide; water / tetrahydrofuran / 18 h / 35 °C / Inert atmosphere
With
manganese(IV) oxide; potassium phosphate tribasic trihydrate; N,N-diisopropyl 2-dicyclohexylphosphino-4-(2',6'-dimethylphenyl)benzamide; water; palladium diacetate; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; dichloromethane; mineral oil;
3.1: |Horner-Wadsworth-Emmons Olefination / 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201301484
