(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

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Chemical Name:(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
CAS No.:905309-75-3
Molecular Formula:C₃₅H₄₂ClIN₂O₇
Molecular Weight:765.085
Hs Code.:

(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Synonyms:(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

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Chemical Property of (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

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Technology Process of (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

There total 18 articles about (3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 905309-77-5
(1S,3Z)-1-allyl-4-iodo-4-phenylbut-3-enyl (2S)-2-({3-[(N-acryloyl-3-chloro-O-methyl-D-tyrosyl)amino]-2,2-dimethylpropanoyl}oxy)-4-methylpentanoate

: 905309-75-3
(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Guidance literature:: Grubbs catalyst first generation; In toluene; at 80 ℃; for 48h;
DOI:10.1021/ol0609356

Reference yield:

: (1Z)-1-iodo-1-phenylhepta-1,6-dien-4-ol

: 905309-75-3
(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Guidance literature:: Multi-step reaction with 3 steps

1.1: amano lipase AK; vinyl acetate / 24 h / 19 °C

1.2: K₂CO₃ / methanol / 2 h / 20 °C

2.1: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 0.25 h / 20 °C

2.2: DIEA; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 0.5 h / 20 °C

2.3: 75 percent / DMAP; DIEA / tetrahydrofuran; benzene / 16 h / 20 °C

3.1: 75 percent / RuCl₂(PCy₃)2(=CHPh) / toluene / 48 h / 80 °C

With morpholine; vinyl acetate; Amano Lipase AK; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene;
DOI:10.1021/ol0609356

Reference yield:

: 905309-66-2
(1Z,4S)-1-iodo-1-phenylhepta-1,6-dien-4-ol

: 905309-75-3
(3S,10R,16S)-10-(3-chloro-4-methoxybenzyl)-16-[(2Z)-3-iodo-3-phenylprop-2-enyl]-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

Guidance literature:: Multi-step reaction with 2 steps

1.1: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 0.25 h / 20 °C

1.2: DIEA; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 0.5 h / 20 °C

1.3: 75 percent / DMAP; DIEA / tetrahydrofuran; benzene / 16 h / 20 °C

2.1: 75 percent / RuCl₂(PCy₃)2(=CHPh) / toluene / 48 h / 80 °C

With morpholine; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene;
DOI:10.1021/ol0609356