1-TERT-BUTOXYCARBONYL-4-(2-NITROPHENYL)PIPERAZINE

Base Information

• Chemical Name: 1-TERT-BUTOXYCARBONYL-4-(2-NITROPHENYL)PIPERAZINE
• CAS No.: 170017-73-9
• Molecular Formula: C15H21 N3 O4
• Molecular Weight: 307.349
• Hs Code.: 2933599090
• Mol file: 170017-73-9.mol

Synonyms:1-(tert-Butoxycarbonyl)-4-(2-nitrophenyl)piperazine;tert-Butyl 4-(2-nitrophenyl)piperazine-1-carboxylate

Chemical Property of 1-TERT-BUTOXYCARBONYL-4-(2-NITROPHENYL)PIPERAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 436.457°C at 760 mmHg
• PKA: 1.28±0.10(Predicted)
• Flash Point: 217.762°C
• PSA: 78.60000
• Density: 1.221g/cm³
• LogP: 3.17800

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-(2-nitrophenyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-TERT-BUTOXYCARBONYL-4-(2-NITROPHENYL)PIPERAZINE

There total 5 articles about 1-TERT-BUTOXYCARBONYL-4-(2-NITROPHENYL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (170017-73-9)

Guidance literature:

Reference yield: 99.0%

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (170017-73-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 17h;

Reference yield: 89.5%

2-Chloronitrobenzene (88-73-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (170017-73-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 130 ℃;

DOI:10.1016/S0960-894X(03)00796-0

upstream raw materials:

ortho-nitrofluorobenzene

1-t-Butoxycarbonylpiperazine

2-Chloronitrobenzene

di-tert-butyl dicarbonate

Downstream raw materials:

1-(2-nitrophenyl)piperazine

3-cyano-4-(2-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester

1-[1,1-dimethylethoxycarbonyl]-4-(2-aminophenyl)piperazine

4-[3-(3-chloro-phenylsulfanyl)-1H-indol-7-yl]-piperazine-1-carboxylic acid tert-butyl ester