(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

Base Information

Chemical Name:(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid
CAS No.:1073314-05-2
Molecular Formula:C₁₅H₁₁FN₄O₂S
Molecular Weight:330.342
Hs Code.:

Synonyms:(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

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Chemical Property of (E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

Chemical Property:

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Technology Process of (E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

There total 4 articles about (E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073314-03-0
(E)-methyl 3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylate

: 1073314-05-2
(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

Guidance literature:: With lithium hydroxide;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1073314-05-2
(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: N,N-dimethyl-formamide / 4 h / 150 °C

4.1: sodium azide; zinc dibromide / 6 h / 100 °C

5.1: tetrahydrofuran / 5 h / Heating / reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: lithium hydroxide

With lithium hydroxide; copper(l) iodide; sodium azide; potassium carbonate; zinc dibromide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 5.1: Wittig Reaction;

Reference yield:

: 1073313-99-1
5-(4-fluorophenyl)-2-formylthiophene-3-carbonitrile

: 1073314-05-2
(E)-3-(5-(4-fluorophenyl)-3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; zinc dibromide / 6 h / 100 °C

2: tetrahydrofuran / 5 h / Heating / reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: lithium hydroxide

With lithium hydroxide; sodium azide; potassium carbonate; zinc dibromide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Wittig Reaction;