(R)-o-(2-fluorophenyl)-2-pyridinemethanol

Base Information

• Chemical Name: (R)-o-(2-fluorophenyl)-2-pyridinemethanol
• CAS No.: 1350476-53-7
• Molecular Formula: C₁₂H₁₀FNO
• Molecular Weight: 203.216
• Mol file: 1350476-53-7.mol

Synonyms:(R)-o-(2-fluorophenyl)-2-pyridinemethanol

Chemical Property of (R)-o-(2-fluorophenyl)-2-pyridinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-o-(2-fluorophenyl)-2-pyridinemethanol

There total 3 articles about (R)-o-(2-fluorophenyl)-2-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-fluorophenyl)(pyridin-2-yl)methanone (6238-65-9) → (R)-o-(2-fluorophenyl)-2-pyridinemethanol (1350476-53-7)

Guidance literature:

With C₃₆H₄₀Cl₂N₂P₂Ru; potassium tert-butylate; In dichloromethane; isopropyl alcohol; at 23 ℃; for 2h; enantioselective reaction;

DOI:10.1021/acscatal.9b01535

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → (R)-o-(2-fluorophenyl)-2-pyridinemethanol (1350476-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; iodine / tetrahydrofuran

1.2: 0 °C

2.1: sodium formate; N-[(1S,2S)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)ethyl]-4-methylbenzenesulfonamide(chloro)ruthenium(II) / water; dimethyl sulfoxide / 50 °C / Inert atmosphere; Schlenk technique

With N-[(1S,2S)-1,2-diphenyl-2-(2-(4-methylbenzyloxy)ethylamino)ethyl]-4-methylbenzenesulfonamide(chloro)ruthenium(II); iodine; sodium formate; magnesium; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/acs.orglett.7b00691

Reference yield:

o-fluorobromobenzene (1072-85-1) + 2-Cyanopyridine (100-70-9,1232006-36-8) → (R)-o-(2-fluorophenyl)-2-pyridinemethanol (1350476-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / Inert atmosphere

1.2: 0 °C / Inert atmosphere

1.3: 0.5 h / Inert atmosphere

2.1: C₆₉H₇₈Cl₂N₂O₆P₂Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 16 h / 25 °C / 6080.41 Torr / Autoclave; Inert atmosphere

With C₆₉H₇₈Cl₂N₂O₆P₂Ru; potassium tert-butylate; hydrogen; magnesium; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jo202204j

upstream raw materials:

o-fluorobromobenzene

2-Cyanopyridine

(2-fluorophenyl)(pyridin-2-yl)methanone