N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

Base Information

• Chemical Name: N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
• CAS No.: 1300734-21-7
• Molecular Formula: C₂₉H₃₂N₆O₄S
• Molecular Weight: 569.605

Synonyms:N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

Chemical Property of N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

There total 4 articles about N-(5-(tert-butyl-D₉)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-aminophenyl)-7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazole (950769-61-6) + phenyl 5-(1,1-dimethylethyl-D9)isoxazol-3-ylcarbamate (1300734-52-4) → N-(5-(tert-butyl-D9)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea (1300734-21-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; at 65 ℃; for 2h; Product distribution / selectivity;

Reference yield:

methyl pivalate-d9 → N-(5-(tert-butyl-D9)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea (1300734-21-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 70 - 75 °C

2: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / pH 6.5 / Reflux

3: potassium carbonate / tetrahydrofuran / 21 h / 0 - 40 °C

4: N-ethyl-N,N-diisopropylamine / dmap / tetrahydrofuran / 2 h / 65 °C

With hydroxylamine hydrochloride; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dmap; In tetrahydrofuran; ethanol; water; mineral oil;

Reference yield:

C7H2(2)H9NO (1300734-50-2) → N-(5-(tert-butyl-D9)isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea (1300734-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / pH 6.5 / Reflux

2: potassium carbonate / tetrahydrofuran / 21 h / 0 - 40 °C

3: N-ethyl-N,N-diisopropylamine / dmap / tetrahydrofuran / 2 h / 65 °C

With hydroxylamine hydrochloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dmap; In tetrahydrofuran; ethanol; water;

upstream raw materials:

2-(4-aminophenyl)-7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazole

phenyl 5-(1,1-dimethylethyl-D₉)isoxazol-3-ylcarbamate

C₇H₂⁽²⁾H₉NO

3-amino-5-(1,1-dimethylethyl-D₉)-isoxazole

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