⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine

Base Information

• Chemical Name: ⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine
• CAS No.: 504414-31-7
• Molecular Formula: C₁₈H₂₃FN₂O₄
• Molecular Weight: 349.392

Synonyms:⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine

Chemical Property of ⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of ⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine

There total 1 articles about ⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-iodyl-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine (1206189-89-0) → (18)F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine (504414-31-7)

Guidance literature:

With source of ¹⁸F^1-; In dimethyl sulfoxide; at 150 ℃; for 0.166667h; Sealed tube;

Reference yield: 75.0%

(18)F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine (504414-31-7) → (18)F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxybenzyl)-(2R,5S)-pyrazine-5'-formate (1206189-95-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 70 ℃; for 0.333333h; Sealed tube;

upstream raw materials:

2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-iodyl-4'-methoxy-5'-formylbenzyl)-(2R,5S)-pyrazine

Downstream raw materials:

⁽¹⁸⁾F-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2'-fluoro-4'-methoxybenzyl)-(2R,5S)-pyrazine-5'-formate

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