ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

Base Information

Chemical Name:ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate
CAS No.:764640-58-6
Molecular Formula:C₂₃H₃₃FN₂O₃
Molecular Weight:404.525
Hs Code.:

Synonyms:ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

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Chemical Property of ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

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Technology Process of ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

There total 3 articles about ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1403502-84-0
C₂₈H₄₁FN₂O₅

: 764640-58-6
ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201204484

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 764640-58-6
ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran; water / 6 h / 0 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 21 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane; water / 0 - 20 °C / Inert atmosphere

With triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.201204484

Reference yield:

: (R)-N-(tert-butoxycarbonyl)-4-fluorophenylalanine

: 764640-58-6
ethyl 1-[2-amino-3-(4-fluorophenyl)propanoyl]-4-cyclohexylpiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 21 h / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane; water / 0 - 20 °C / Inert atmosphere

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1002/anie.201204484