5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1059065-52-9
Molecular Formula:C₂₂H₁₇BrClN₃O
Molecular Weight:454.753
Hs Code.:

Synonyms:5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 7 articles about 5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1059065-50-7
tert-butyl 4-(3-(2-bromobenzyl)-7-chloro-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)phenylcarbamate

: 1059065-52-9
5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: tert-butyl 4-(3-(2-bromobenzyl)-7-chloro-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)phenylcarbamate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;

With sodium hydroxide; In dichloromethane; water; pH=> 10;

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 1059065-52-9
5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 21 h / 20 - 32 °C

2.1: acetic acid / 8 h / 130 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 5 h / 20 - 90 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / -15 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

7.2: pH > 10

With ammonium cerium (IV) nitrate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium carbonate; acetic acid; N,N-dimethyl-aniline; trifluoroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1059065-44-9
(E)-5,7-Dichloro-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1059065-52-9
5-(4-aminophenyl)-3-(2-bromobenzyl)-7-chloro-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 3 h / -15 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

4.2: pH > 10

With ammonium cerium (IV) nitrate; potassium tert-butylate; sodium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;