methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Base Information

Chemical Name:methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate
CAS No.:1265396-65-3
Molecular Formula:C₂₉H₃₅N₃O₂
Molecular Weight:457.616
Hs Code.:

Synonyms:methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Chemical Property of methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

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Technology Process of methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

There total 13 articles about methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 3973-62-4
3-phenylpiperidine

: 1265393-37-0
methyl 2-(2-chloro-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

: 1265396-65-3
methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 110 ℃; for 5h; Sealed tube;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265396-65-3
methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 21 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: water; chloroacetic acid / 20 h / Reflux

4.1: thionyl chloride / 48 h / 0 °C / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C

7.1: triethylamine / tetrahydrofuran / 5 h / 110 °C / Sealed tube

With thionyl chloride; water; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; chloroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265396-65-3
methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -78 °C

2.2: 3 h / -15 - 20 °C

3.1: triethylamine / tetrahydrofuran / 5 h / 110 °C / Sealed tube

With triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;