(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

Base Information

Chemical Name:(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid
CAS No.:170157-60-5
Molecular Formula:C₁₂H₁₃Cl₃N₂O₃
Molecular Weight:339.606
Hs Code.:

Synonyms:(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

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Chemical Property of (S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

Chemical Property:

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Technology Process of (S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

There total 1 articles about (S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34891-76-4
2,2,2-trichloro-N-(hydroxymethyl)acetamide

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 170157-60-5
(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

Guidance literature:: With sulfuric acid; at 20 ℃; for 1h;
DOI:10.1021/jo00070a048

Reference yield:

: 170157-60-5
(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

: 845730-78-1
(S)-2-tert-Butoxycarbonylamino-3-[4-(isopropylamino-methyl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2-methyl-propan-2-ol / Ambient temperature

2: 41 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature

3: H₂, 4 Angstroem molecular sieves / 10percent Pd/C / 26 h

With sodium hydroxide; 4 A molecular sieve; hydrogen; palladium on activated charcoal; In ethanol; tert-butyl alcohol;
DOI:10.1021/jm00014a017

Reference yield:

: 170157-60-5
(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

: 170157-63-8
L-N^α-Boc-N⁴-Cbz-4-<(isopropylamino)methyl>phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 2-methyl-propan-2-ol / Ambient temperature

2: 41 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature

3: H₂, 4 Angstroem molecular sieves / 10percent Pd/C / 26 h

4: tetrahydrofuran; H₂O

With sodium hydroxide; 4 A molecular sieve; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;
DOI:10.1021/jm00014a017