2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone

Base Information

• Chemical Name: 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone
• CAS No.: 220806-38-2
• Molecular Formula: C₁₄H₁₈O₃S
• Molecular Weight: 266.361
• Mol file: 220806-38-2.mol

Synonyms:2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone

Chemical Property of 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone

There total 1 articles about 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 5-dimethoxymethyl-2-thiophenecarboxaldehyde (5370-68-3) → 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone (220806-38-2)

Guidance literature:

With sodium hydroxide; water;

DOI:10.1002/(sici)1521-3765(19990104)5:1<369::aid-chem369>3.0.co;2-5

Reference yield: 28.0%

5-piperidin-1-yl-thiophene-2-carbaldehyde (24372-48-3) + 2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone (220806-38-2) → 5-<2-oxo-3-<(E)-1-(5-piperidino-2-thienyl)methylidene>cyclohexylidenemethyl>-2-thiophenecarboxaldehyde (220806-43-9)

Guidance literature:

With sodium hydroxide; water; In ethanol; at 100 ℃; for 96h;

DOI:10.1002/(sici)1521-3765(19990104)5:1<369::aid-chem369>3.0.co;2-5

Reference yield:

2-<(E)-1-<(5-dimethoxymethyl)-2-thienyl>methylidene>-1-cyclohexanone (220806-38-2) → (E)-2-Cyano-3-{5-[2-oxo-3-[1-(5-piperidin-1-yl-thiophen-2-yl)-meth-(E)-ylidene]-cyclohex-(E)-ylidenemethyl]-thiophen-2-yl}-acrylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / NaOH, H₂O / ethanol / 96 h / 100 °C

2: 43 percent / piperidine / toluene / 60 °C

With piperidine; sodium hydroxide; water; In ethanol; toluene;

DOI:10.1002/(sici)1521-3765(19990104)5:1<369::aid-chem369>3.0.co;2-5

upstream raw materials:

cyclohexanone

5-dimethoxymethyl-2-thiophenecarboxaldehyde

Downstream raw materials:

5-<2-oxo-3-<(E)-1-(5-piperidino-2-thienyl)methylidene>cyclohexylidenemethyl>-2-thiophenecarboxaldehyde