(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

Base Information

Chemical Name:(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol
CAS No.:871912-62-8
Molecular Formula:C₁₉H₂₆O₅
Molecular Weight:334.412
Hs Code.:

Synonyms:(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

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Chemical Property of (2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

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Technology Process of (2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

There total 8 articles about (2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4R,5S)-4-(2-Methyl-allyl)-2-phenyl-5-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-[1,3,2]dioxaborinane

: 871912-62-8
(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

Guidance literature:: With dihydrogen peroxide; In ethyl acetate; at 23 ℃; for 1h;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4R,5R)-5-((1R,2R)-1-Formyl-2-hydroxy-4-methyl-pent-4-enyloxy)-2-phenyl-[1,3]dioxane-4-carbaldehyde

: 871912-62-8
(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaBH₄ / methanol / 1 h / 0 °C

2.1: 100 percent / benzene / 0.5 h / 23 °C

3.1: DMPI / CH₂Cl₂ / 21 h / 23 °C

4.1: NHMDS / tetrahydrofuran / 1 h / 23 °C

4.2: tetrahydrofuran / 2 h / -78 - 23 °C

5.1: H₂O₂ / ethyl acetate / 1 h / 23 °C

With sodium tetrahydroborate; dimethyl pimelimidate dihydrochloride; dihydrogen peroxide; sodium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; benzene; 3.1: Dess-Martin oxidation / 4.1: Wittig reaction;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4aR,6S,8aS)-6-((R)-1-Hydroxy-3-methyl-but-3-enyl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 871912-62-8
(2S,3R)-5-Methyl-2-((2R,4S,5R)-2-phenyl-4-vinyl-[1,3]dioxan-5-yloxy)-hex-5-ene-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaIO₄ / dioxane; H₂O / 1 h / 23 °C

2.1: NaBH₄ / methanol / 1 h / 0 °C

3.1: 100 percent / benzene / 0.5 h / 23 °C

4.1: DMPI / CH₂Cl₂ / 21 h / 23 °C

5.1: NHMDS / tetrahydrofuran / 1 h / 23 °C

5.2: tetrahydrofuran / 2 h / -78 - 23 °C

6.1: H₂O₂ / ethyl acetate / 1 h / 23 °C

With sodium tetrahydroborate; sodium periodate; dimethyl pimelimidate dihydrochloride; dihydrogen peroxide; sodium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; benzene; 4.1: Dess-Martin oxidation / 5.1: Wittig reaction;
DOI:10.1016/j.tetlet.2005.09.164