5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester
CAS No.:1027501-43-4
Molecular Formula:C₃₇H₃₅FO₉
Molecular Weight:642.678
Hs Code.:

Synonyms:5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

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Chemical Property of 5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

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Technology Process of 5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

There total 7 articles about 5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152609-85-3
ethyl 3-<4-<7-carbomethoxy-9-oxo-3-<3-<2-ethyl-5-(benzyloxy)-4-(4-fluorophenyl)phenoxy>propoxy>-9H-xanthene>>propanoate

: 1027501-43-4
5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm00076a030

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 1027501-43-4
5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 100 percent / NaI / butan-2-one / 6 h / Heating

6: 69 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

7: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; potassium carbonate; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In tetrachloromethane; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 152609-59-1
1-benzyloxy-4-ethyl-3-(3-chloro-1-propyloxy)-benzene

: 1027501-43-4
5-(2-Ethoxycarbonyl-ethyl)-6-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

2: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

3: 100 percent / NaI / butan-2-one / 6 h / Heating

4: 69 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

5: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; potassium carbonate; sodium iodide; palladium on activated charcoal; In tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006