N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

Base Information

• Chemical Name: N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester
• CAS No.: 23556-66-3
• Molecular Formula: C₃₁H₅₀N₄O₉
• Molecular Weight: 622.759

Synonyms:N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

Chemical Property of N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

Chemical Property:

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Technology Process of N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

There total 3 articles about N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Z-Lys(Boc)-OH (2389-60-8) + N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester (23556-66-3)

Guidance literature:

Z-Lys(Boc)-OH; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1021/acs.orglett.0c00036

Reference yield:

(S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate (3017-32-1,1372256-52-4) + Z-Lys(Boc)-OH (2389-60-8) → N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester (23556-66-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

→ N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester (23556-66-3)

Guidance literature:

Lys(Boc)-OMe, Z-Lys(Boc), DCC;

DOI:10.1002/hlca.19610440121

upstream raw materials:

Z-Lys(Boc)-OH

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

(S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate

Downstream raw materials:

Z-Lys(Boc)-Lys(Boc)-NH-NH₂

Z-L-Lys(Boc)-L-Lys(Boc)-OH

N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butoxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester

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