2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

Base Information

Chemical Name:2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide
CAS No.:1621421-67-7
Molecular Formula:C₂₃H₂₇N₃O₅
Molecular Weight:425.484
Hs Code.:

Synonyms:2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

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Chemical Property of 2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

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Technology Process of 2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

There total 6 articles about 2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 914389-37-0,914389-38-1
(+/-)-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one

: 1621422-12-5
(R)-N-(4-methoxyphenyl)oxirane-2-carboxamide

: 1621421-67-7
2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

: 1621421-99-5
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

Guidance literature:: With triethylamine; In ethanol; for 0.166667h; Heating; Microwave irradiation;

Reference yield:

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 1621421-67-7
2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

: 1621421-99-5
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -45 °C

1.2: 1 h / -45 °C

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

3.1: lithium bromide; sodium tetrahydroborate / methanol / 12 h

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1621421-76-8
1-(tert-butoxycarbonyl) 2-(methoxycarbonyl)pyrrolidine-2-carboxylic acid

: 1621421-67-7
2-hydroxy-N-(4-methoxyphenyl)-3-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

: 1621421-99-5
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

2: lithium bromide; sodium tetrahydroborate / methanol / 12 h

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

5: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide; In tetrahydrofuran; methanol; ethanol; dichloromethane;